- King Promise: Singer, songwriter, and producer known for his hit songs such as "Oh Yeah", "Commando", and "Slow Down".
- Sarkodie: Rapper and entrepreneur, widely regarded as one of the most successful and influential musicians in Ghana. Known for songs like "Adonai", "Illuminati", and "Lucky".
- Shatta Wale: Reggae-dancehall artist, known for his controversial and provocative style. Some of his popular songs include "Dancehall King", "Kakai", and "Ayoo".
- Stonebwoy: Afropop, dancehall, and reggae artist known for his hits like "Bawasaaba", "Go Higher", and "Nominate".
- Efya: Soulful singer, songwriter, and vocalist, known for songs such as "One of Your Own", "Best in Me", and "Until the Dawn".
- M.anifest: Hip hop artist and rapper, known for his fusion of local sounds with contemporary hip hop. Some of his popular songs include "Someway Bi", "No Where Cool", and "GodMC".
- Bisa Kdei: Highlife singer, songwriter, and producer known for his hit songs such as "Asew", "Brother Brother", and "Mansa".
- Wendy Shay: Afropop and Afrobeat musician known for her hits such as "Uber Driver", "Stevie Wonder", and "All for You".
- Kuami Eugene: Highlife and Afrobeat singer, songwriter, and producer known for songs like "Angela", "Wish Me Well", and "Open Gate".
- Fantana: Singer and songwriter known for her hit songs "Girls Hate On Girls", "So What", and "Touch Me".
It's important to note that musical success and popularity can vary over time, and there are many other talented musicians in Ghana who may have contributed significantly to the country's music scene. Additionally, musical preferences are subjective, so different individuals may have their own opinions about who they consider the best musician in Ghana.