Driving Jefferson City, MO → Toronto: ~1,240 Miles, 19–20 Hours

The most direct driving route from Missouri's capital to Canada's largest city spans ~1,240 miles (2,000 km) and takes 19–20 hours of pure driving — realistically 2.5–3 days with stops.

Primary Route

1. I-70 E (Jefferson City → St. Louis) — 125 mi
2. I-70 E / I-64 E (St. Louis → Indianapolis) — 240 mi
3. I-70 E (Indianapolis → Columbus) — 175 mi
4. I-71 N (Columbus → Cleveland) — 140 mi
5. I-90 E (Cleveland → Buffalo) — 185 mi
6. I-190 N → Peace Bridge (Buffalo → Fort Erie, ON) — 5 mi + border
7. QEW → Hwy 403 → Hwy 401 (Fort Erie → Toronto) — 150 km

Border Crossing

• Peace Bridge (Buffalo/Fort Erie): Busiest; NEXUS lane saves 30–60 min.
• Alternatives: Lewiston-Queenston (I-190 → Hwy 405), Rainbow Bridge (downtown Niagara Falls).
• Have passport / enhanced DL / NEXUS / FAST. Check CBP wait times.

Practical Advice

• Split it: Night 1: Jefferson City → Columbus, OH (5.5 hr). Night 2: Columbus → Toronto (7.5 hr + border).
• Fuel: Fill in US — Ontario gas ~30% pricier.
• Weather: Lake-effect snow near Cleveland/Buffalo Nov–Apr; check forecasts.
• Currency: Get CAD before crossing or use no-FX-fee card.

It's a haul — but a classic Midwest-to-Great-Lakes road trip.