No incorporated city in the United States bears the name Regina. The name is most prominently associated with Regina, Saskatchewan—the capital city of that Canadian province, population approximately 230,000.
Several unincorporated U.S. communities share the name (e.g., Regina, New Mexico; Regina, Kentucky), but none are designated as cities. The name derives from Latin for "queen," bestowed on the Canadian city in 1882 to honor Queen Victoria.
Americans seeking a "Regina" experience might consider Regina, New Mexico—a tiny railroad community along historic Route 66—or Regina, Kentucky, in the Appalachian foothills. Neither offers municipal services or governance structures of an incorporated city.