The Distrito Nacional is the most densely populated part of Santo Domingo, with over 1 million people living in an area of just over 100 square kilometers. The city center is located in the Distrito Nacional, and it is home to many of the city's most important landmarks, including the Catedral Primada de América (the first cathedral in the Americas), the Alcázar de Colón (the former palace of Christopher Columbus), and the Parque Independencia (Independence Park).
Santo Domingo Este is located on the eastern side of the Ozama River, and it is home to over 1.5 million people. Santo Domingo Este is a rapidly growing area, and it is home to many new residential developments, as well as the Parque Mirador del Este (East Viewpoint Park).
Santo Domingo Oeste is located on the western side of the Ozama River, and it is home to over 1 million people. Santo Domingo Oeste is also a rapidly growing area, and it is home to many new residential developments, as well as the Parque Jardín Botánico Nacional (National Botanical Garden Park).
Santo Domingo Norte is located on the northern side of the city, and it is home to over 700,000 people. Santo Domingo Norte is a more rural area, and it is home to many farms and small towns.