According to the FBI's 2023 Uniform Crime Report, St. Louis, Missouri, recorded the highest violent crime rate among major U.S. cities: 2,065.60 incidents per 100,000 residents. The city also had the highest murder rate at 65.66 per 100,000.
Crime rates fluctuate annually and can vary by reporting methodology. Rankings often change when considering different crime categories (property vs. violent) or metropolitan areas vs. city proper. Always consult the latest data for current assessments.