The Spanish Inquisition, formally established in the Americas in 1569 (Mexico) and 1570 (Peru), extended the Iberian machinery of religious persecution to the New World. Its impact on indigenous populations was catastrophic and multidimensional.
The Inquisition's mandate: enforce Catholic orthodoxy. Indigenous "idolatry" (traditional religion) was heresy. Auto de fe (public penance/burning) ceremonies terrorized communities. Resistance = relapse = death. Children were primary targets for "re-education" in missions.
Systematic destruction: Codices burned (only 4 Maya codices survive), temples razed (stones reused for churches), priests executed, calendars suppressed, languages marginalized in favor of Spanish/Latin. The Extirpación de Idolatrías campaigns (Peru, 1610s+) institutionalized cultural genocide.
Encomienda and repartimiento forced labor justified as "Christianization." Mit'a (Andean draft labor) redirected to Potosí silver mines. Mortality: 80%+ in some mining cohorts. Inquisition investigated "mistreatment" only when it impeded conversion.
Synergy of disease (smallpox, measles, typhus), violence, displacement, overwork, and cultural despair. Mexico: ~25M → ~1M (1519–1600). Peru: ~12M → ~1.5M. Inquisition didn't cause epidemics but prevented indigenous healing practices and concentrated populations in reducciones (mission towns) that accelerated spread.
Inquisition fines/penalties paid in land/labor. "Idle" communal lands seized for Spanish estates. Legal fiction: terra nullius applied to "uncultivated" indigenous territories.
Inquisition policed racial boundaries: limpieza de sangre (purity of blood) determined office-holding, marriage, testimony rights. Mixed-race populations (mestizo, mulatto, zambo) created—but hierarchically ranked.
Indigenous women targeted for "concubinage," accused of witchcraft/brujería when resisting. Inquisition records document systematic abuse by clergy and officials.
Indigenous governance, education, medicine, astronomy, agriculture disrupted. Surviving knowledge went underground (syncretism: Virgin of Guadalupe = Tonantzin; Andean saints = apus). The Inquisition ended (1820s), but its epistemic violence shapes Latin American inequality today.