- Start from San Antonio and take I-35 S to US-281 S.
- Follow US-281 S for approximately 145 miles.
- This route will take you directly to Eagle Pass.
Route 2 via TX-16 & US-281:
- Start from San Antonio and take TX-16 S towards Bandera.
- Continue on TX-16 S for about 101 miles.
- Turn right onto US-281 S and follow it for around 45 miles.
- This route offers scenic countryside views but is slightly longer than Route 1.