In 1706, no European power formally claimed Colorado. The region was inhabited by Ute, Apache, Comanche, and Arapaho peoples. Spanish claims dated to 1541 (Coronado expedition) but were notional; France claimed the Mississippi watershed (including eastern Colorado) in 1682 (La Salle). The U.S. acquired most of Colorado via the Louisiana Purchase (1803) from France; the southwestern corner came via the Mexican Cession (1848). Formal U.S. territorial organization began with Colorado Territory in 1861.