The driving distance from Apache Junction, Arizona to the Grand Canyon South Rim (the most visited and accessible rim) is approximately 155 miles (250 km) via the most direct route (US-60 W to AZ-79 N to AZ-77 N to AZ-377 N to AZ-260 W to US-180 W to AZ-64 W).
Estimated Drive Time: 2.5 to 3 hours under normal traffic and road conditions.
Note: The North Rim is significantly farther (~300+ miles, 5+ hours) and is only open seasonally (mid-May to mid-October). Always check NPS Grand Canyon for current road conditions, closures, and entrance fees.