Many major cities worldwide are perched at elevations exceeding 6,000 feet (1,829 meters). Most are in the Andes or on the Mexican Plateau. Here are prominent examples:
| City | Country | Elevation (ft) | Elevation (m) | Notes |
|---|---|---|---|---|
| La Paz (administrative capital) | Bolivia | 11,942 | 3,640 | Highest capital city; sprawling across a canyon. |
| Cusco | Peru | 11,155 | 3,400 | Former Inca capital; gateway to Machu Picchu. |
| Quito | Ecuador | 9,350 | 2,850 | Second-highest capital; UNESCO historic center. |
| Bogotá | Colombia | 8,660 | 2,640 | Highest capital of a large nation; vast metropolis. |
| Mexico City | Mexico | 7,350 | 2,240 | One of the world's largest cities; in the Valley of Mexico. |
| Addis Ababa | Ethiopia | 7,726 | 2,355 | African Union HQ; Entoto Mountains backdrop. |
| Tehran | Iran | 3,900–5,800 | 1,200–1,770 | Parts of the metro area exceed 6,000 ft. |
| Johannesburg | South Africa | 5,751 | 1,753 | Just below 6,000 ft; major economic hub. |
High altitude brings hypoxia (lower oxygen), intense UV radiation, cooler temperatures, and unique health considerations (altitude sickness, chronic mountain sickness). Residents adapt physiologically (increased hematocrit) and culturally (architecture, agriculture, pace of life).