Sedona, Arizona sits about 115 miles (185 km) from the Grand Canyon's South Rim—a drive of roughly 2 hours and 15 minutes via US-89A and US-180 through Flagstaff. The North Rim is farther (about 140 miles, 3+ hours) and only open seasonally.
The most direct route climbs from Sedona's red rocks through Oak Creek Canyon—one of Arizona's most scenic drives—before reaching the high plateau country around Flagstaff. From there, US-180 heads northwest to the park entrance.
Many visitors combine the trip with a loop through the Navajo Nation, adding stops at Sunset Crater Volcano, Wupatki National Monument, and the Cameron Trading Post before entering the park via the East Entrance (Desert View Drive). This adds an hour but delivers vastly more scenery and cultural context.
Whichever route you choose, leave early to secure parking at the South Rim and allow time for viewpoints along Desert View Drive.