Based on 2021 U.S. Census Bureau estimates, here are the populations and pairwise differences for four major U.S. cities.
| City | Population | Rank |
|---|---|---|
| Chicago | 2,746,388 | 3 |
| Houston | 2,304,580 | 4 |
| San Francisco | 815,201 | 17 |
| Boston | 675,647 | 24 |
| Comparison | Difference | Larger City |
|---|---|---|
| Chicago – Houston | 441,808 | Chicago |
| Chicago – San Francisco | 1,931,187 | Chicago |
| Chicago – Boston | 2,070,741 | Chicago |
| Houston – San Francisco | 1,489,379 | Houston |
| Houston – Boston | 1,628,933 | Houston |
| San Francisco – Boston | 139,554 | San Francisco |
City proper populations ≠ metro reality — but they define tax base, governance, and identity.