The drive from Geneva to Lyon is straightforward: ~165 km (103 miles) via the A40 (France) and A46, taking about 1 hour 45 minutes in normal traffic.
The route crosses the border at Bardonnex/St-Julien-en-Genevois. Have your passport/ID ready. Traffic can build during rush hours and ski weekends. Vignette (toll sticker) required for Swiss motorways; French autoroutes use péage (pay tolls).