No, there is no major city located 600 miles west of Boston along Lake Erie.
Boston is situated on the northeastern coast of the United States. Lake Erie lies in the Midwest, bordering New York, Pennsylvania, Ohio, and Michigan. The straight-line distance from Boston to the eastern tip of Lake Erie (near Buffalo, NY) is roughly 400–450 miles. Traveling 600 miles west from Boston would place you well past Lake Erie, likely in the vicinity of Chicago or southern Lake Michigan.
The primary major cities on Lake Erie include:
None of these are 600 miles west of Boston. The premise of the question conflates the distance and geography of the Northeast and the Great Lakes regions.