Determine what mode of transport you want to use. There are several ways to get from Prague to Vienna such as by train, bus or on a fancy cruise. To make a decision, keep in mind the time you will be leaving, the time it will take to complete the journey and how much it will cost. Get in touch with the local railway and bus station for exact, up-to-date details on fares and schedules.
Go to the railway station if you have decided to travel by train. Tickets can be bought both from the station and online. A train ticket from Prague to Vienna will cost less than 40 Euros per person, as of January 2011. The Prague train station offers discounts to groups of more than six people for the journey to Vienna. It will take you around six hours to reach Vienna by train. The main railway station Hlavni Nadrazi is at Wilsonova 8, New Town, Prague 2.
Go to the UAN Florenc Bus Station, located close to the main Railway Station, if you want to travel by bus. The bus route actually is shorter than traveling by train -- around four hours from Prague to Vienna. Because the tickets are also cheaper - less than 25 Euros per person, traveling by bus is a viable option. There is Wi-Fi and a movie on-board.
Drive to Vienna if you want to experience all the scenery on the way, first-hand. The journey is around 350 kilometers and will take less than four hours to complete. Rent a car from Prague Airport, Prague Downtown or Hilton Hotel Prague, with the smallest car costing 162 Euros a week.
Take a cruise from Prague to Vienna along the river Danube for an enchanting vacation. There are several famous cruises you can book online with some offering a 10-day stay including travel, from Prague to Vienna. Rates start from around $2000 per person, including breakfast.