* The endangered Appalachian elk (Cervus canadensis canadensis) is a large, majestic creature that once roamed the forests of the eastern United States in great numbers. However, due to overhunting and habitat loss, the Appalachian elk was nearly wiped out by the early 20th century. Today, the Appalachian elk is federally endangered and protected. There are only about 200 Appalachian elk left in the world, and most of them live in the Great Smoky Mountains National Park.
* The threatened Carolina madtom (Noturus furiosus) is a small, catfish-like fish that lives in the French Broad River and its tributaries. The Carolina madtom is threatened by habitat loss and pollution.
* The endangered smoky madtom (Noturus baileyi) is a small, catfish-like fish that lives in the French Broad River and its tributaries. The smoky madtom is threatened by habitat loss and pollution.
* The threatened yellowfin madtom (Noturus flavipinnis) is a small, catfish-like fish that lives in the French Broad River and its tributaries. The yellowfin madtom is threatened by habitat loss and pollution.