The driving distance from Puebla, Puebla to Cancún, Quintana Roo is approximately 1,250 km (777 miles) via the primary highway route.
Mexico 150D / 180D / 190D / 180 / 307 — Puebla → Córdoba → Veracruz → Coatzacoalcos → Villahermosa → Campeche → Mérida → Cancún.
Mostly 4-lane toll highways (cuota) — good condition. Free roads (libre) parallel but slower, through towns. Watch for: topes (speed bumps), wildlife, fog (Veracruz coast), holiday traffic (Semana Santa, Christmas).
Driving is scenic (Gulf coast, jungles, Yucatán plains) but long. Flying is standard for this distance.