- Explored Florida in 1513, becoming the first European to do so.
- Landed in St. Augustine and took possession of it for Spain.
- Also led expeditions to Puerto Rico and Cuba.
Hernán Cortés:
- Led the Spanish expedition that conquered the Aztec Empire in Mexico from 1519 to 1521.
- Defeated the Aztec emperor Montezuma and established Spanish control over Mexico.
- His conquest established Spain as the dominant power in the region.