- Rio San Juan: This river forms part of the border between Nicaragua and Costa Rica. It flows from Lake Nicaragua into the Caribbean Sea.
- Rio Coco: Also known as the Rio Segovia, this river forms the border between Nicaragua and Honduras. It flows into the Caribbean Sea.
- Rio Grande de Matagalpa: This river flows through the central region of Nicaragua and empties into the Caribbean Sea.
- Rio Escondido: This river flows through the southern region of Nicaragua and empties into the Pacific Ocean.
- Rio Rama: This river flows through the southeastern region of Nicaragua and empties into the Caribbean Sea.