The drive from Lampasas to Midland, Texas covers approximately 143 miles (230 km) via the most direct routing.
US-183 North → I-20 West
Lampasas → Lometa → Goldthwaite → US-183 N → I-20 W at Cisco → Midland
Time: ~2 hours 15 minutes (normal traffic)
US-84 West → US-83 North → I-20 West: ~155 miles, 2 hr 30 min. More scenic (Hill Country).
US-281 North → I-20 West: ~150 miles, 2 hr 25 min. Via Hamilton, Stephenville.
Midland (pop. ~110K) = Permian Basin heart, oil/finance center. Midland Int'l Airport (MAF) between cities. Odessa (twin city) 20 miles west.
Fill up in Lampasas or Goldthwaite. Cell coverage spotty on US-183 north of Goldthwaite.