Most hummingbirds—primarily the Ruby-throated Hummingbird—depart North Carolina between late September and October, triggered by shortening daylight and cooling temperatures.
By early November, the vast majority have migrated to wintering grounds in Mexico and Central America. A few stragglers may linger at well-stocked feeders into November, especially in coastal areas, but this is uncommon.
Pro tip: Keep feeders up until two weeks after you see the last bird—it won't delay migration (instinct drives that) but provides critical fuel for late migrants passing through.