- The South Platte River: Originating in the Rocky Mountains, the South Platte River flows through the Front Range and the plains region before joining the North Platte River in Nebraska.
- The Arkansas River: Rising in the Sawatch Range, the Arkansas River flows southeastward through Colorado and into Kansas and Oklahoma.
- The Colorado River: Starting in the Rocky Mountains, the Colorado River flows through western Colorado before continuing through Utah, Arizona, Nevada, and California, eventually reaching the Gulf of California.
- The Rio Grande: Originating in the San Juan Mountains, the Rio Grande flows south through Colorado and New Mexico before forming the border between Texas and Mexico and eventually emptying into the Gulf of Mexico.
- The Gunnison River: Flowing from the West Elk Mountains, the Gunnison River joins the Colorado River in western Colorado.
- The White River: Originating in the Flat Tops Wilderness Area, the White River flows through northwestern Colorado before joining the Green River in Utah.
