Travel to Manaus, Brazil. It is a popular starting point for trips down the Amazon.
Do some research once you get to Manaus. There are a good number of cruises that let you gently see the scenery. There are also smaller tour ships that let you get up close and personal with the rain forest setting.
Prepare yourself for the trip by gathering information on the plants and animals. This area boasts one of the largest variety of species in the world.
Consider taking a detour to see the Inca Amazon Trail. The ancient Inca civilization created some of the most breathtaking monuments and pyramids on the planet.