Key West: The Southernmost City in the Continental U.S.

Yes, Key West is the southernmost city in the contiguous United States.

Located at 24.5551° N, 81.7800° W, it sits at the end of the Florida Keys archipelago—a ~120-mile chain of coral cay islands connected by the Overseas Highway (US-1). It is 90 miles (145 km) from Cuba—closer to Havana than to Miami (160 mi).

Clarifications

• "City" vs. "Point": The Southernmost Point Buoy (tourist landmark) marks the continental U.S. extremity. The actual southernmost land is Ballast Key (private, 9 miles west), but Key West is the southernmost incorporated city.
• Hawaii is further south: Honolulu (21.3° N) and Naalehu (19.0° N) are farther south, but Hawaii is non-contiguous.
• Territories: Pago Pago, American Samoa (14.3° S) is the southernmost U.S. capital.