Hilton Head, SC to Greenville, NC: ~165 Miles by Road

The driving distance from Hilton Head Island, South Carolina to Greenville, North Carolina is approximately 165 miles (266 km). The route typically follows US-278 to I-95 North, then US-264 East or similar, taking about 3 to 3.5 hours depending on traffic and exact locations.

Hilton Head is a coastal resort island; Greenville is an inland city in the Piedmont region. The drive crosses the Coastal Plain and passes through areas like Walterboro, SC, and Rocky Mount, NC.