Spanish explorers continued to sail along the eastern coast of South America in search of wealth and new lands to conquer. In 1516, Juan Díaz de Solís was killed by natives while leading an expedition to the Río de la Plata. In 1520, Ferdinand Magellan's expedition became the first to circumnavigate the world, and it also explored the eastern coast of South America.
Later Spanish explorers who sailed along the eastern coast of South America include:
- Sebastián Cabot (1526-1527)
- Diego García (1526-1527)
- Simon de Alcazaba y Sotomayor (1534-1535)
- Francisco de Orellana (1541-1542)
- Jerónimo Luis de Cabrera (1573)
- Juan de Garay (1580)
These explorers explored the eastern coast of South America for various reasons, including searching for wealth and new lands to conquer, as well as seeking a passage to Asia.