Historical evidence contradicts the claim that the Yamassee migrated from Florida to South Carolina. The Yamassee were an Iroquoian-speaking people originally inhabiting the coastal regions of present-day Georgia and South Carolina.
In the early 1700s, they were allied with British traders but grew resentful of exploitation. The Yamassee War (1715–1717) erupted—a pan-tribal uprising against South Carolina colonists. The Yamassee were devastated: many killed, others enslaved, survivors scattered.
Post-war dispersal:
So the movement was from the Carolinas/Georgia to Florida—not the reverse. The Yamassee were victims of colonial expansion, not migrants from Spanish Florida.