- Juan Perez de la Marcha, a Portuguese explorer, explored California and made detailed maps of the coast.
- The Spanish established the San Francisco Presidio, one of the first European settlements in California.
- Mission San Antonio de Padua, the third Spanish mission in California, was founded in the Salinas Valley.
- Several European diseases, including smallpox, were introduced to the native population of California, resulting in a significant decline in their numbers.