No. San Francisco is not the single most likely epicenter. California sits atop a network of active faults—the San Andreas system is just one. Major faults include:
The Uniform California Earthquake Rupture Forecast (UCERF3) models probabilities across all faults. While the 1906 SF quake (M7.9) was devastating, the next "Big One" could nucleate anywhere on the system. Southern California (LA Basin, Inland Empire) has higher cumulative probability due to fault density.
Science cannot predict exact epicenters. It forecasts probabilities over decades. Preparedness (retrofit, water, plan) matters more than location guessing.