Mission Santa Clara de Asís (founded 1777, relocated 1781, 1784, 1791 — current site 1825) was placed at the Guadalupe River in the Santa Clara Valley for strategic reasons:
Large village So-co-is-su-ka (Thámien) at the river — primary conversion target. Franciscans sought dense populations for labor and souls.
Perennial flow (spring-fed from Santa Cruz Mtns) — irrigation for wheat, corn, beans, vegetables, vineyards, orchards; drinking, livestock, mills.
Valley floor — deep, well-drained, nutrient-rich. "Llano de Uvas" (Plain of Grapes) — became California's first wine region.
Mediterranean — mild winters, dry summers, 300+ growing days. Ideal for Mediterranean crops (wheat, grapes, olives, figs).
Mid-peninsula — anchor for northern expansion; buffer between coastal and interior tribes.
By 1830: 1,500+ neophytes, 10,000+ livestock, 5,000+ bushels grain, vineyards, tannery, gristmill. Secularization (1834) ended mission control; lands granted to Californios. Santa Clara University (1851) occupies the final mission site.
The site was a calculated nexus of water, soil, people, and transport — the Franciscan formula for a self-sustaining colonial node.