Distance: ~110 miles (177 km) via interstate highways.
| Route | Distance | Time (no traffic) |
|---|---|---|
| I-75 S → FL-92 W (Tamiami Trail) | 110 mi | 2 hr 1 min |
| I-275 S → FL-64 W (Pine Island Rd) | 115 mi | 2 hr 15 min |
| US-41 N (Tamiami Trail, scenic) | 125 mi | 3 hr 26 min |
I-75 is fastest and most direct. US-41 passes through Everglades (Shark Valley, Big Cypress) for scenery. Traffic around Tampa/St. Pete and Fort Myers rush hours can add 30–60 minutes.