Wanderlust World Wanderlust World Oregon and Missouri sit on opposite sides of the continental United States—Oregon in the Pacific Northwest and Missouri in the Midwest. The straight-line distance between their geographic centers is roughly 1,742 miles (2,804 kilometers).
If you prefer a road trip, plan for a drive of about 2,240 miles (3,599 kilometers) via Interstate 80 or Interstate 70, depending on your starting point in Oregon. Expect 32 to 35 hours behind the wheel, not counting stops for fuel, meals, and rest.
For a faster option, direct flights connect Portland, Oregon, with major Missouri cities such as St. Louis and Kansas City. The flight time averages 3 to 4 hours, making air travel the most time-efficient choice.