Driving Distance: Key West, FL to Pittsburgh, PA ≈ 1,140 Miles

The road distance from Key West, Florida to Pittsburgh, Pennsylvania is approximately 1,140 miles (1,835 km). Driving time: ~18–20 hours nonstop (typically 2–3 days with stops). Route: US-1 north to Florida's Turnpike → I-75 → I-24 → I-71 → I-76 (PA Turnpike) to Pittsburgh.