- Hydropower: The river's flow is harnessed by several dams, including the Kariba Dam, which produces hydroelectricity for Zambia and Zimbabwe.
- Irrigation: The river's waters are used to irrigate crops in agricultural areas in Zambia, Zimbabwe, and Mozambique.
- Water supply: The river is a major source of water for human consumption, industrial use, and livestock.
- Transportation: The river is navigable by boat and barge for certain stretches, facilitating trade and transport.
- Tourism and Recreation: The Zambezi River is renowned for its scenic beauty and is a popular tourist destination for activities like white-water rafting, canoeing, and safaris.