Home air conditioners, if not central air units, sit in windows. This blocks out light and reduces air circulation when it is turned off. They also take away from the appearance of your home interior.
RV air conditioners sit on the roof or in the basement. This means that none of the windows are blocked so they're not reducing light or ventilation in the RV.
RV air conditioners can run off of AC or DC current. Home air conditioners can only run off AC current.
House units come in one piece units while RV units come in two pieces. One piece is mounted on the outside of the roof and the other piece is mounted inside the RV.
RV air conditioners, unlike house air conditioners, can have heat strips added to them to convert the unit into a heater.