What is the most expensive hotel in San Diego?

As of my knowledge up to August, 2021, the most expensive hotel in San Diego is The Lodge at Torrey Pines. It is a five-star luxury resort located perched atop the cliffs of Torrey Pines State Natural Reserve, offering stunning views of the Pacific Ocean. Prices for a standard room start at around $900 per night, and suites can range up to $2,500 per night or even higher. Hotel pricing is very dynamic, so it is best to check the hotel's website for the most up-to-date pricing information.