No Direct Bus Service: North Carolina to Fort Myers, Florida

There is no direct intercity bus route connecting North Carolina to Fort Myers, Florida. Major carriers (Greyhound, FlixBus, Megabus) do not offer through-service or coordinated connections between these points.

Practical Alternatives

• Fly: Charlotte (CLT) or Raleigh (RDU) → Southwest Florida Int'l (RSW) ~2h flight.
• Drive: ~700–850 miles (11–13 hours) via I-95 S / I-75 S.
• Multi-leg bus (not recommended): Would require Greyhound to Atlanta or Orlando, then transfer to local/regional carriers—exceeding 24 hours with multiple layovers.

For cost/time efficiency, flying or driving are the only realistic options.