The road distance from Denver, Colorado to Grand Teton National Park is approximately 480 miles (772 km).
Typical drive time: 8 hours under normal conditions via I-25 N → I-80 W → US-191 N (or similar routing). Actual time varies with traffic, weather, roadwork, and stops.
Most direct route passes through Cheyenne, WY; Laramie; Rock Springs; Jackson, WY (gateway to the park). Scenic alternative: US-287 N through Fort Collins and Walden.