The most important thing to remember when crossing the U.S./Canadian border with insulin in any form (i.e., pill or syringe) is to have proper pharmaceutical proof that it is yours. If you lack proper documentation, the border patrol will search your vehicle and confiscate your insulin. There is also the possibility that you will be fined or prevented from crossing the border.
If you are traveling with a pet that requires insulin in any form, you must have a letter from your veterinarian stating that the insulin has been prescribed for your pet. As is the case with humans, lack of proper documentation will result in a vehicle search and confiscation of your pet's insulin.
As of 1999, both the United States and Canada accept the Canadian Commercial Driver's License (CDL) from commercial drivers as proof of their medical fitness. However, the United States prohibits drivers who are insulin-dependent from crossing into and operating commercial vehicles in the United States. Even Canadian drivers who have received waivers, exemptions or grandfather rights to operate within Canada are forbidden to operate commercial vehicles in the United States. As of 2006, the Federal Motor Carrier Safety Administration was considering relaxing these rules for diabetic truckers.