1. Great Falls of the Missouri River: Located in present-day Montana, the Great Falls consist of five waterfalls along a 10-mile stretch of the Missouri River.
2. Three Forks of the Missouri River: At this point in present-day Montana, the Missouri River is formed by the confluence of three rivers: the Jefferson, Madison, and Gallatin rivers.
3. Lemhi Pass: Located in the Bitterroot Mountains of present-day Idaho, Lemhi Pass was a crucial crossing point for the expedition on their journey westward.
4. Clearwater River: The expedition explored and named the Clearwater River, a major tributary of the Snake River in present-day Idaho.
5. Bitterroot Mountains: Lewis and Clark encountered and named the Bitterroot Mountains, a mountain range in present-day Idaho and Montana.
6. Lolo Pass: Another important crossing point for the expedition, Lolo Pass is a mountain pass through the Bitterroot Mountains.
7. Columbia River: The expedition reached and explored the Columbia River, a major river system in the Pacific Northwest.
8. Pacific Ocean: The ultimate goal of the expedition, Lewis and Clark finally reached the Pacific Ocean, becoming the first Americans to do so overland.
9. Multnomah Falls: On their return journey, Lewis and Clark discovered and named Multnomah Falls, the tallest waterfall in Oregon.
10. Cape Disappointment: Located at the mouth of the Columbia River, Cape Disappointment was named due to the disheartening realization that the expedition had not found a viable water route across the continent.