Can a US pilot fly over Mecca?

Yes, a US pilot can technically fly over Mecca, but it is unlikely to happen in reality. The airspace above Mecca is considered a restricted area by the Saudi Arabian government, and it is not open to commercial or general aviation flights. While there may be some exceptions for diplomatic or military flights, it is generally understood that pilots should avoid flying over the area out of respect for the religious significance of Mecca.