How long does it take to drive from Memphis San Diego?

You can't drive from Memphis to San Diego. Memphis is located in Tennessee, while San Diego is located in California. The two cities are separated by the entire width of the United States, and there is no direct route between them. The shortest route between the two cities is via Interstate 40 and Interstate 5, which is a distance of approximately 2,400 miles. Driving this route would take approximately 40 hours, depending on traffic and weather conditions.