>Estimated distance: 780 miles (1,260 km)
>Approximate travel time: 12 hours
Take I-75 South from Cincinnati, Ohio.
Continue on I-75 South to Atlanta, Georgia.
Follow signs for I-26 East to Charleston, South Carolina.
Stay on I-26 East to Savannah, Georgia.
Continue on I-26 East to Hilton Head Island, South Carolina.
Option 2: Via Interstate 40
>Estimated distance: 810 miles (1,310 km)
>Approximate travel time: 12.5 hours
Take I-71 South from Cincinnati, Ohio.
Continue on I-71 South to Nashville, Tennessee.
Take I-40 East from Nashville to Knoxville, Tennessee.
Stay on I-40 East to Charlotte, North Carolina.
Follow signs for I-26 East to Charleston, South Carolina.
Continue on I-26 East to Savannah, Georgia.
Stay on I-26 East to Hilton Head Island, South Carolina.