Distance from Panama City, Florida to Disneyland in California: No Direct Route

Panama City, Florida and Disneyland (Anaheim, California) are on opposite coasts of the United States—roughly 2,300 miles (3,700 km) apart by air. There is no single direct driving route; a cross-country road trip would take 35+ hours via I-10 W and I-5 N (or similar interstates), while a flight connects in 5–6 hours with a layover.

If you meant Panama City Beach, Florida to Walt Disney World (Orlando, Florida), the drive is about 300 miles (4.5–5 hours) via I-10 E and I-75 S / Florida’s Turnpike.

Always confirm which "Disney" and which "Panama City" you’re referencing before planning travel.