There are no non-stop flights between London and Brisbane. The quickest one-stop option typically routes through Singapore:
Other common hubs include Dubai (DXB), Doha (DOH), Hong Kong (HKG), and Kuala Lumpur (KUL), with similar total journey times of 21–24 hours including connections. Qantas, Singapore Airlines, British Airways, and Emirates are the primary carriers on this route.
Future ultra-long-haul aircraft (e.g., Airbus A350-1000ULR, Boeing 777X) may eventually enable direct service, but for now, a single stop in Southeast Asia or the Gulf remains the standard.