Approximate driving distance: 275 miles between Holderness, New Hampshire (Grafton County town) and Manhattan, New York (NYC borough).
Route typically follows I-93 S → I-95 S through New Hampshire, Massachusetts, Connecticut, into New York. Travel time ~4.5–5.5 hours depending on traffic, especially NYC approach.
Clarification: Both are towns/boroughs, not cities. Manhattan is a borough of New York City.