Correction: A flight from Rio de Janeiro (GIG/SBGL) to Santiago (SCL) does not cross the Andes.
Great-circle route: Rio (22.9° S, 43.2° W) → South/Southwest over the South Atlantic Ocean → Chilean coast near Concepción → North along coast to Santiago. Total distance ~2,900 km (1,800 mi); flight time ~4h 30m nonstop.
On a clear day, left-side passengers (facing forward) may glimpse the Andes' snowcapped peaks after crossing the Chilean coast, running parallel to the flight path south of Santiago — but the aircraft does not overfly them.
Nonstop operators: LATAM, Sky Airline, JetSMART (seasonal).