* The bubonic plague first appeared in Europe in the 14th century. The pandemic, known as the Black Death, killed an estimated 75-200 million people in Europe, about one-third of the population.
* The bubonic plague also spread to Asia and Africa. It is estimated that the plague killed more than 100 million people in Asia and Africa.
* The bubonic plague had a profound impact on the history of Europe, Asia, and Africa. The pandemic caused widespread social and economic disruption, and it led to the development of new public health measures and quarantine procedures.
* The bubonic plague is still a threat today. Although the disease is now rare, it can still be fatal if not treated promptly.