Madagascar lies off the east coast of Africa, in the Indian Ocean, separated from Mozambique by the ~400 km-wide Mozambique Channel. It is the world's fourth-largest island (after Greenland, New Guinea, and Borneo), spanning 587,041 km²—larger than France or Thailand.
Map projections (especially Mercator) distort the channel's width and can make Madagascar appear closer to the southern tip of Africa. Some older texts ambiguously refer to the "southeast coast of Africa." But every standard geographic reference places it east.
Flights from Europe typically connect via Paris (Air France), Addis Ababa (Ethiopian), Istanbul (Turkish), or Nairobi (Kenya Airways). From North America, connections through Europe or the Middle East are standard. No direct flights exist from the Americas.