In the late 15th century, European powers—especially Portugal and Spain—sought a direct sea route to Asia (the "Indies") to bypass Ottoman-controlled land routes and access the lucrative spice, silk, and luxury trades.
Christopher Columbus, sailing for Spain in 1492, underestimated Earth's circumference and overestimated Asia's eastward extent. He believed a westward voyage of ~3,000 miles would reach Japan (Cipangu). Instead, at roughly that distance, he encountered the Bahamas, Cuba, and Hispaniola—the fringes of a continental landmass unknown to Europe, Africa, and Asia.
The genuine western sea route to Asia was finally opened by Ferdinand Magellan's expedition (1519–1522), which sailed around South America (Strait of Magellan) across the Pacific to the Philippines and Spice Islands (Moluccas). But the Americas—initially an obstacle—became the focus of empire.